Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

INTRODUCTION In human cells, 2 m of DNA are compacted in the nucleus through
assembly with histones and other proteins into chromatin structures, megabase three …

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA
replication and repair, and chromosome segregation. This structure, however, remains …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

Whereas the core nucleosome is thought to serve as a packaging device for the coiling and
contraction in length of genomic DNA, we suggest that it serves primarily in the regulation of …

It would often be useful in computer simulations to use an implicit description of solvation
effects, instead of explicitly representing the individual solvent molecules. Continuum …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

The hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional
regulation and other DNA-related biological processes. Here, we report the 11-angstrom …

Genomic DNA in the eukaryotic nucleus is hierarchically packaged by histones into
chromatin to fit inside the nucleus. The dynamics of higher-order chromatin compaction play …