Immunotherapy has emerged as a key pillar of cancer treatment. To build upon the recent
successes of immunotherapy, intense research efforts are aimed at a molecular …

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Triple-negative breast cancer (TNBC) represents a more aggressive and difficult subtype of
breast cancer where responses to chemotherapy occur, but toxicity is significant and …

There is an increasing awareness of the importance of tumor–immune cell interactions to the
evolution and therapy responses of breast cancer (BC). Not surprisingly, numerous studies …

Phenotypic heterogeneity has been observed in most malignancies, which represents a
considerable challenge for tumor therapy. In recent decades, the biological function and …

Regulatory T cells, a subpopulation of suppressive T cells, are potent mediators of self-
tolerance and essential for the suppression of triggered immune responses. The immune …

Tumor-infiltrating lymphocytes (TILs) have been known for their strong prognostic and
predictive significance in triple-negative breast cancer (TNBC). Several mechanisms for TIL …

Aberrant induction of human leukocyte antigen-G (HLA-G) expression has been observed in
various malignancies and is strongly associated with tumor immune escape, metastasis and …

Highlights•Breast cancer is the most frequently diagnosed cancer in women.•Aberrant
expression of HATs and HDACs has been reported in breast cancer.•Epigenetic therapy is …

HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …