Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Background Alzheimer's disease (AD) is the commonest cause of dementia, with
approximately 5 million new cases occurring annually. Despite decades of research, its …

Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …

Nineteen organoselenides were synthesized and tested for their intrinsic cytotoxicity in
hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines and their …

Background: Evidence has revealed an association between familial hypercholesterolemia
and cognitive impairment. In this regard, a connection between cognitive deficits and …

Hypercholesterolemia is a known contributor to the pathogenesis of Alzheimer's disease
while its role in the occurrence of Parkinson's disease (PD) is only conjecture and far from …

Abstract The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …

Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …

Objective While chronic feeding with high-fat or high-sugar diets is known related to obesity
and type 2 diabetes, later data have indicated that it is also related to depression and …