Clinical pharmacokinetics of metformin
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac) …
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac) …
Drug transport by organic anion transporters (OATs)
G Burckhardt - Pharmacology & therapeutics, 2012 - Elsevier
Common to all so far functionally characterized Organic Anion Transporters (OATs) is their
broad substrate specificity and their ability to exchange extracellular against intracellular …
broad substrate specificity and their ability to exchange extracellular against intracellular …
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy
AT Nies, H Koepsell, K Damme, M Schwab - Drug transporters, 2011 - Springer
Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …
Drug transporters in drug efficacy and toxicity
MK DeGorter, CQ Xia, JJ Yang… - Annual review of …, 2012 - annualreviews.org
Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease
M Noetzli, CB Eap - Clinical pharmacokinetics, 2013 - Springer
With the aging population and its rapidly increasing prevalence, dementia has become an
important public health concern in developed and developing countries. To date, the …
important public health concern in developed and developing countries. To date, the …
Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy
K Inoue, H Yuasa - Drug metabolism and pharmacokinetics, 2014 - jstage.jst.go.jp
Methotrexate (MTX) is a derivative of folic acid (folate) and commonly used as an anchor
drug for the treatment of rheumatoid arthritis (RA). The pharmacokinetics (PK) and …
drug for the treatment of rheumatoid arthritis (RA). The pharmacokinetics (PK) and …
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
Y Chen, S Li, C Brown, S Cheatham… - Pharmacogenetics …, 2009 - journals.lww.com
Objective The goal of this study was to determine the effect of a genetic variant in the organic
cation transporter 2 (OCT2), OCT2-808G/T, which results in an amino acid change, A270S …
cation transporter 2 (OCT2), OCT2-808G/T, which results in an amino acid change, A270S …
In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy
G Burckhardt, BC Burckhardt - Drug Transporters, 2011 - Springer
Abstract Organic anion transporters 1-10 (OAT1-10) and the urate transporter 1 (URAT1)
belong to the SLC22A gene family and accept a huge variety of chemically unrelated …
belong to the SLC22A gene family and accept a huge variety of chemically unrelated …
Is metformin a perfect drug? Updates in pharmacokinetics and pharmacodynamics
M Markowicz-Piasecka, KM Huttunen… - Current …, 2017 - ingentaconnect.com
Metformin, a synthetic biguanide, is currently one of the most frequently recommended
medications for type 2 diabetes treatment around the world. This review presents the latest …
medications for type 2 diabetes treatment around the world. This review presents the latest …
Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation
AT Nies, E Schaeffeler, M Schwab - Pharmacology & Therapeutics, 2022 - Elsevier
Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …