Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Glomerular hyperfiltration

M Cortinovis, N Perico, P Ruggenenti… - Nature reviews …, 2022 - nature.com
Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in
the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the …

[HTML][HTML] Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

G Tang, S Li, C Zhang, H Chen, N Wang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes
mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious …

The tubular hypothesis of nephron filtration and diabetic kidney disease

V Vallon, SC Thomson - Nature Reviews Nephrology, 2020 - nature.com
Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

The global epidemiology of diabetes and kidney disease

DN Koye, DJ Magliano, RG Nelson… - Advances in chronic kidney …, 2018 - Elsevier
The prevalence of diabetes is increasing worldwide, with the greatest increases occurring in
low-and middle-income countries. In most developed countries, type 2 diabetes is presently …

The epidemiology of diabetic kidney disease

EK Hoogeveen - Kidney and Dialysis, 2022 - mdpi.com
Globally, the incidence and prevalence of diabetes mellitus has risen dramatically, owing
mainly to the increase in type 2 diabetes mellitus (T2DM). In 2021, 537 million people …

Pathogenic pathways and therapeutic approaches targeting inflammation in diabetic nephropathy

S Rayego-Mateos, JL Morgado-Pascual… - International journal of …, 2020 - mdpi.com
Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting
in elevated cost for public health systems. DN is the main cause of chronic kidney disease …

Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease

MC Thomas, ME Cooper, P Zimmet - Nature Reviews Nephrology, 2016 - nature.com
Chronic kidney disease (CKD) is a common comorbidity in patients with type 2 diabetes
mellitus (T2DM) and both conditions are increasing in prevalence. CKD is estimated to …

Signaling pathways involved in diabetic renal fibrosis

Y Zhang, D Jin, X Kang, R Zhou, Y Sun… - Frontiers in cell and …, 2021 - frontiersin.org
Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …