Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes
mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious …

The prevalence of diabetes is increasing worldwide, with the greatest increases occurring in
low-and middle-income countries. In most developed countries, type 2 diabetes is presently …

Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …

Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting
in elevated cost for public health systems. DN is the main cause of chronic kidney disease …

Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in
the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the …

Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Chronic kidney disease (CKD) is a common comorbidity in patients with type 2 diabetes
mellitus (T2DM) and both conditions are increasing in prevalence. CKD is estimated to …

Sodium-glucose cotransporter-2 (SGLT2) is selectively expressed in the human kidney,
where it executes reabsorption of filtered glucose with a high capacity; it may be overactive …

The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …