Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine

MA Sánchez-Garrido, D García-Galiano… - Human …, 2022 - academic.oup.com
BACKGROUND According to the Developmental Origins of Health and Disease (DOHaD)
hypothesis, environmental changes taking place during early maturational periods may alter …

Multi-and transgenerational effects of environmental toxicants on mammalian reproduction

P Rebuzzini, G Fabozzi, D Cimadomo, FM Ubaldi… - Cells, 2022 - mdpi.com
Environmental toxicants (ETs) are an exogenous chemical group diffused in the
environment that contaminate food, water, air and soil, and through the food chain, they …

[HTML][HTML] Isoflavones alter male and female fertility in different development windows

HK Sleiman, JM de Oliveira, GBL de Freitas - Biomedicine & …, 2021 - Elsevier
Isoflavones are a group of secondary metabolites found in plants belonging to the class of
phytoestrogens. These, because they have a chemical structure similar to the endogenous …

The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration

X Hu, X Li, P Deng, Y Zhang, R Liu, D Cai… - Critical Reviews in …, 2023 - Taylor & Francis
Androgen is a kind of steroid hormone that plays a vital role in reproductive system and
homeostasis of the body. Disrupted androgen balance serves as the causal contributor to a …

Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler …

N Ye, Z Lv, Z Huang, Y Cheng, Q Wei, F Shi - Theriogenology, 2022 - Elsevier
The aging phenomenon often exerts a significant reduction in the reproduction performance
of aged animals. The objective of this project was to investigate the effects of dietary Folic …

Dietary alpha-lipoic acid supplementation improves spermatogenesis and semen quality via antioxidant and anti-apoptotic effects in aged breeder roosters

N Ye, Z Lv, H Dai, Z Huang, F Shi - Theriogenology, 2021 - Elsevier
The purpose of the present study was to investigate the effects of dietary alpha-lipoic acid
(ALA) supplementation on the reproductive performance of aged breeder roosters. Sixteen …

Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

LJ Martin, M Touaibia - Nutrients, 2024 - mdpi.com
Androgen production primarily occurs in Leydig cells located in the interstitial compartment
of the testis. In aging males, testosterone is crucial for maintaining muscle mass and …

Genistein lowers fertility with pronounced effect in males: Meta‐analyses on pre‐clinical studies

R Rashid, A Kumari, N Chattopadhyay, R Jha… - Andrologia, 2022 - Wiley Online Library
Genistein, an isoflavonoid, is found in a plethora of plant‐based foods, and has been
approved for use in various therapies. A couple of studies in adult men observed a negative …

[HTML][HTML] Consumption of soy isoflavones during the prepubertal phase delays puberty and causes hypergonadotropic hypogonadism with disruption of hypothalamic …

JM Oliveira, IM Oliveira, HK Sleiman, GO Dal Forno… - Toxicology Letters, 2022 - Elsevier
Isoflavones are phytoestrogens with recognized estrogenic activity but may also affect
testosterone, corticosterone and thyroid hormone levels in experimental models. However …

Reproductive disruption in adult female and male rats prenatally exposed to mesquite pod extract or daidzein

F Solano, E Hernández, L Juárez-Rojas… - Reproductive …, 2022 - Elsevier
Phytoestrogens are considered to be endocrine disruptors, since they can alter the
endocrine system, thus disturbing many reproductive events. The intake of diets containing a …