Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Recent evidence indicates that diverse neurodegenerative diseases might have a common
cause and pathological mechanism—the misfolding, aggregation and accumulation of …

Tissue deposition of normally soluble proteins as insoluble amyloid fibrils is associated with
serious diseases including the systemic amyloidoses, maturity onset diabetes, Alzheimer's …

Acetylcholinesterase (AChE), an important component of cholinergic synapses, colocalizes
with amyloid-β peptide (Aβ) deposits of Alzheimer's brain. We report here that bovine brain …

Structural studies of Alzheimer's amyloid fibrils have revealed information about the structure
at different levels. The amyloid-β peptide has been examined in various solvents and …

Protein aggregation is arguably the most common and troubling manifestation of protein
instability, encountered in almost all stages of protein drug development. Protein …

Fibrillogenesis of the amyloid β-protein (Aβ) is a seminal pathogenetic event in Alzheimer's
disease. Inhibiting fibrillogenesis is thus one approach toward disease therapy. Rational …

Inhibition of cerebral amyloid β-protein deposition seems to be an important target for
Alzheimer's disease therapy. Amyloidogenesis could be inhibited by short synthetic peptides …

Alzheimer's disease is characterized by extensive cerebral amyloid deposition. Amyloid
deposits associated with damaged neuropil and blood vessels contain abundant fibrils …

Publisher Summary The chapter discusses the structural analysis of amyloid fibrils by
electron microscopy and X-ray diffraction. A method to isolate amyloid fibrils from tissue was …