Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

RHB Benedict, MP Amato, J DeLuca… - The Lancet …, 2020 - thelancet.com
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Recommendations for cognitive screening and management in multiple sclerosis care

R Kalb, M Beier, RHB Benedict… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Purpose: To promote understanding of cognitive impairment in multiple sclerosis (MS),
recommend optimal screening, monitoring, and treatment strategies, and address barriers to …

Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype

B Hou, Y Zhang, P Liang, Y He, B Peng, W Liu… - Cell Death & …, 2020 - nature.com
Multiple sclerosis (MS) is a chronic disease that is characterized by demyelination and
axonal damage in the central nervous system. Cognitive deficits are recognized as one of …

Brief International Cognitive Assessment for MS (BICAMS): international standards for validation

RHB Benedict, MP Amato, J Boringa, B Brochet… - BMC neurology, 2012 - Springer
An international expert consensus committee recently recommended a brief battery of tests
for cognitive evaluation in multiple sclerosis. The Brief International Cognitive Assessment …

Risk factors for and management of cognitive dysfunction in multiple sclerosis

RHB Benedict, R Zivadinov - Nature Reviews Neurology, 2011 - nature.com
Cognitive impairment is common in multiple sclerosis (MS), especially when assessed by
neuropsychological tests that emphasize mental processing speed, episodic memory, and …

Cognitive impairment in multiple sclerosis: clinical, radiologic and pathologic insights

GC DeLuca, RL Yates, H Beale, SA Morrow - Brain pathology, 2015 - Wiley Online Library
Cognitive impairment is a common and debilitating feature of multiple sclerosis (MS) that
has only recent gained considerable attention. Clinical neuropsychological studies have …

Treatment optimization in MS: Canadian MS Working Group updated recommendations

MS Freedman, D Selchen, DL Arnold, A Prat… - Canadian Journal of …, 2013 - cambridge.org
The Canadian Multiple Sclerosis Working Group (CMSWG) developed practical
recommendations in 2004 to assist clinicians in optimizing the use of disease-modifying …

Predicting loss of employment over three years in multiple sclerosis: clinically meaningful cognitive decline

SA Morrow, A Drake, R Zivadinov… - The clinical …, 2010 - Taylor & Francis
Cognitive dysfunction is common in multiple sclerosis (MS), yet the magnitude of change on
objective neuropsychological (NP) tests that is clinically meaningful is unclear. We …

Cognitive impairment in early stages of multiple sclerosis

MP Amato, E Portaccio, B Goretti, V Zipoli, B Hakiki… - Neurological …, 2010 - Springer
Abstract Cognitive dysfunction involves 40–65% of multiple sclerosis patients and can have
a great functional impact. It can be detected in all the disease phenotypes since the early …

Relevance of cognitive deterioration in early relapsing-remitting MS: a 3-year follow-up study

MP Amato, E Portaccio, B Goretti… - Multiple Sclerosis …, 2010 - journals.sagepub.com
Objective: To assess longitudinally cognitive functioning in relapsing—remitting multiple
sclerosis (RRMS) patients and its relationship with clinical and MRI variables. Methods …