Current status of microbes involved in the degradation of pharmaceutical and personal care products (PPCPs) pollutants in the aquatic ecosystem
Contamination of aquatic systems with pharmaceuticals, personal care products, steroid
hormones, and agrochemicals has been an immense problem for the earth's ecosystem and …
hormones, and agrochemicals has been an immense problem for the earth's ecosystem and …
Data-independent acquisition (DIA): an emerging proteomics technology for analysis of drug-metabolizing enzymes and transporters
Data-independent acquisition (DIA) proteomics is a recently-developed global mass
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …
Nonalcoholic fatty liver disease and diabetes are associated with decreased CYP3A4 protein expression and activity in human liver
R Jamwal, SM De La Monte, K Ogasawara… - Molecular …, 2018 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease in the
Western population. We investigated the association of nonalcoholic fatty liver disease …
Western population. We investigated the association of nonalcoholic fatty liver disease …
A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism
Abstract Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity
and cancers (eg lung and bladder cancer), since it is responsible for metabolizing a number …
and cancers (eg lung and bladder cancer), since it is responsible for metabolizing a number …
Perfluorooctanesulfonic acid and perfluorohexanesulfonic acid alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity
Perfluoroalkyl substances (PFAS) represent a family of environmental toxicants that have
infiltrated the living world. This study explores diet-PFAS interactions and the impact of …
infiltrated the living world. This study explores diet-PFAS interactions and the impact of …
Discovery of the consistently well-performed analysis chain for SWATH-MS based pharmacoproteomic quantification
Sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS)
has emerged as one of the most popular techniques for label-free proteome quantification in …
has emerged as one of the most popular techniques for label-free proteome quantification in …
Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice
Hepatic steatosis increases risk of fatty liver and cardiovascular disease.
Perfluorooctanesulfonic acid (PFOS) is a persistent, bio-accumulative pollutant that has …
Perfluorooctanesulfonic acid (PFOS) is a persistent, bio-accumulative pollutant that has …
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism
Little is known about the impact of morphological disorders in distinct zones on metabolic
zonation. It was described recently that periportal fibrosis did affect the expression of CYP …
zonation. It was described recently that periportal fibrosis did affect the expression of CYP …
Nonalcoholic fatty liver disease (NAFLD) and hepatic cytochrome P450 (CYP) enzymes
R Jamwal, BJ Barlock - Pharmaceuticals, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat in the liver. An
international consensus panel has recently proposed to rename the disease to metabolic …
international consensus panel has recently proposed to rename the disease to metabolic …
Per-and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes
SMS Modaresi, W Wei, M Emily, NA DaSilva, AL Slitt - Toxicology, 2022 - Elsevier
The Per-and polyfluoroalkyl substances (PFAS) are a wide group of fluorinated compounds,
which the health effects of many of them have not been investigated. Perfluorinated …
which the health effects of many of them have not been investigated. Perfluorinated …