[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics

MJ Peluso, SG Deeks - Cell, 2024 - cell.com
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease

K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …

Unveiling the potential pleiotropic effects of metformin in treating COVID-19: A comprehensive review

P Petakh, I Kamyshna, A Kamyshnyi - Frontiers in Molecular …, 2023 - frontiersin.org
This review article explores the potential of metformin, a medication commonly used for type
2 diabetes, as an antiviral and anti-inflammatory agent in the context of coronavirus disease …

Old drug, new tricks: the utility of metformin in infection and vaccination responses to influenza and SARS-CoV-2 in older adults

DE Martin, AN Cadar, JM Bartley - Frontiers in Aging, 2023 - frontiersin.org
In the face of global pathogens such as influenza (flu) and severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), strategies beyond standard vaccines and virus …

Cornerstone Cellular pathways for metabolic disorders and Diabetes Mellitus: non-coding RNAs, wnt signaling, and AMPK

K Maiese - Cells, 2023 - mdpi.com
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Clinical Depression, the Mechanistic Target of Rapamycin (mTOR), and Forkhead Transcription Factors (FoxOs)

K Maiese - Current Neurovascular Research, 2023 - ingentaconnect.com
Depression is a disorder in the mental health of an individual that leads to a low level of
activity and feelings of despair and hopelessness [1-3]. Depression can lead to the inability …

[HTML][HTML] Metformin: Beyond Type 2 Diabetes Mellitus

R Ahmad, M Haque - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Metformin was developed from an offshoot of Guanidine. It is known to be the first-line
medication for type 2 diabetes mellitus, polycystic ovarian syndrome, and weight reduction …

Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2: A review of pharmacological effects and mechanism of action

Y Liang, X Quan, R Gu, Z Meng, H Gan, Z Wu, Y Sun… - Heliyon, 2024 - cell.com
Following the coronavirus disease-2019 outbreak caused by severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2), there is an ongoing need to seek drugs that …

Meeting the Challenge of Controlling Viral Immunopathology

E Berber, S Mulik, BT Rouse - International Journal of Molecular Sciences, 2024 - mdpi.com
The mission of this review is to identify immune-damaging participants involved in antiviral
immunoinflammatory lesions. We argue these could be targeted and their activity changed …