Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …

In the last 40 years, male reproductive health—which is very sensitive to both environmental
exposure and metabolic status—has deteriorated and the poor sperm quality observed has …

Eukaryotic chromosomes are folded into higher-order conformations to coordinate genome
functions. In addition to long-range chromatin loops, recent chromosome conformation …

In recent years it has been recognized that the development of cancer involves a series of
not only genetic but epigenetic changes across the genome. At the same time, connections …

Objective To characterize the phenotype of patients with distal myopathy with vocal cord and
pharyngeal weakness due to the p. S85C mutation in the matrin‐3 gene (MATR3, Mendelian …

The eukaryotic genetic material is packaged in the form of chromatin by wrapping DNA
around nucleosomes. Cells maintain chromatin in a dynamic state by utilising various ATP …

Lamin A-related progeroid syndromes are genetically determined, extremely rare and
severe. In the past ten years, our knowledge and perspectives for these diseases has widely …

There is an extensive list of primary published work related to the nuclear matrix (NM). Here
we review the aspects that are required to understand its relationship with DNA replication …

Increasing evidence has demonstrated that abnormal epigenetic modifications are strongly
related to cancer initiation. Thus, sensitive and specific detection of epigenetic modifications …

HOXA9 is commonly upregulated in acute myeloid leukemia (AML), in which it confers a
poor prognosis. Characterizing the protein interactome of endogenous HOXA9 in human …