In addition to well-defined DNA repair pathways, all living organisms have evolved
mechanisms to avoid cell death caused by replication fork collapse at a site where …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

Leading-strand template aberrations cause helicase–polymerase uncoupling and impede
replication fork progression, but the details of how uncoupled forks are restarted remain …

Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which
specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is …

Stalled DNA replication forks activate specific DNA repair mechanism called post-replication
repair (PRR) pathways that simply bypass DNA damage. The bypassing of DNA damage by …

The modification of eukaryotic proteins by covalent attachment of ubiquitin is a versatile
signaling event with a wide range of possible consequences. Canonical poly-ubiquitination …

The double-stranded conformation of cellular DNA is a central aspect of DNA stabilisation
and protection. The helix preserves the genetic code against chemical and enzymatic …

The primase/polymerase PRIMPOL restarts DNA synthesis when replication is arrested by
template impediments. However, we do not have a comprehensive view of how PRIMPOL …

To ensure efficient and timely replication of genomic DNA, organisms in all three kingdoms
of life possess specialized translesion DNA synthesis (TLS) polymerases (Pols) that tolerate …

Living organisms not only repair DNA damage induced by environmental agents and
endogenous cellular metabolites, but have also developed mechanisms to survive in the …