MALAT1/mir-1-3p mediated BRF2 expression promotes HCC progression via inhibiting the LKB1/AMPK signaling pathway

GZ Li, GX Meng, GQ Pan, X Zhang, LJ Yan, RZ Li… - Cancer Cell …, 2023 - Springer
Background The long non-coding RNA metastasis-associated lung adenocarcinoma
transcript 1 (MALAT1) has been reported to play a vital role in the occurrence and …

In silico approaches for drug repurposing in oncology: a scoping review

BRR Cavalcante, RD Freitas… - Frontiers in …, 2024 - frontiersin.org
Introduction: Cancer refers to a group of diseases characterized by the uncontrolled growth
and spread of abnormal cells in the body. Due to its complexity, it has been hard to find an …

BRF2 is mediated by microRNA-409-3p and promotes invasion and metastasis of HCC through the Wnt/β-catenin pathway

JH Chang, BW Xu, D Shen, W Zhao, Y Wang… - Cancer Cell …, 2023 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Its
invasiveness and ability to metastasize contributes to an extremely high patient mortality …

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

B Rashidieh, AL Bain, SM Tria, S Sharma… - … Hematology & Oncology, 2023 - Springer
Background αB-Crystallin is a heat shock chaperone protein which binds to misfolded
proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers …

[HTML][HTML] Fundamentals of molecular docking and comparative analysis of protein–small-molecule docking approaches

SF Maden, S Sezer, SE Acuner - Molecular Docking-Recent …, 2022 - intechopen.com
Abstract Proteins (eg, enzymes, receptors, hormones, antibodies, transporter proteins, etc.)
seldom act alone in the cell, and their functions rely on their interactions with various …

Comprehending the pharmacological mechanism of marine phenolic acids in bladder cancer therapy against matrix metalloproteinase 9 protein by integrated network …

M Roney, MN Uddin, MFFM Aluwi - Computational Biology and Chemistry, 2024 - Elsevier
Bladder cancer (BC) is the 10th most common tumour with a high incidence and recurrence
rate worldwide; however, the current therapies present limitations as, regularly, not all …

Targeting BRF2: insights from in silico screening and molecular dynamic simulations

AS Rathore, KK Gupta, SK Govindaraj… - Journal of …, 2023 - Taylor & Francis
Abstract The Transcription factor II B (TFIIB)‑related factor 2 (BRF2) containing TFIIIB
complex recruits RNA polymerase III multi-subunit complex to selective gene promoters that …

Selenium Metabolic Pathway in Ferroptotic Cell Death

K Kalishwaralal, A Abhishek, CK Keerthana… - Ferroptosis in Health …, 2023 - Springer
Selenoproteins play a crucial role in various complex biological processes, including cell
growth, differentiation, apoptosis, and ferroptosis. In response to increased oxidative …

[PDF][PDF] Transcriptome analysis provides

K Li, J Yan, S Wang, C Zhu, Q Zhu, S Lu, P Hu… - 2024 - frontiersin.org
Vegetables and fruits are considered rich sources of antioxidants that can scavenge oxygen-
free radicals to protect cells from damage caused by oxidative stress (1). Sulforaphane …

Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin

K Li, J Yan, S Wang, C Zhu, Q Zhu, S Lu… - Frontiers in Veterinary …, 2024 - frontiersin.org
This study presents a comprehensive transcriptome analysis of canine intestinal epithelial
cells following treatment with sulforaphane (SFN), a naturally occurring compound found in …