Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion
of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous …

It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …

Fatty acids (FAs) and other lipid molecules are important for many cellular functions,
including vesicle exocytosis. For the pancreatic β-cell, while the presence of some FAs is …

Paraphrasing the Swiss physician and father of toxicology Paracelsus (1493–1541) on
chemical agents used as therapeutics,“the dose makes the poison,” it is now realized that …

The reduction in insulin secretory capacity and β-cell mass observed in type 2 diabetes is
thought to be caused by glucolipotoxicity secondary to hyperglycemia and hyperlipidemia …

The importance of mitochondrial biosynthesis in stimulus secretion coupling in the insulin-
producing β-cell probably equals that of ATP production. In glucose-induced insulin …

Cellular redox state is an important metabolic variable, influencing many aspects of cell
function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH …

The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion
(GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid …