How do sensory neurons sense danger signals?

CR Donnelly, O Chen, RR Ji - Trends in neurosciences, 2020 - cell.com
Sensory neurons are activated by physical and chemical stimuli, eliciting sensations such as
temperature, touch, pain, and itch. From an evolutionary perspective, sensing danger is …

Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain

AJ McFarland, MS Yousuf, S Shiers, TJ Price - Pain reports, 2021 - journals.lww.com
SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …

[HTML][HTML] Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury

W Renthal, I Tochitsky, L Yang, YC Cheng, E Li… - Neuron, 2020 - cell.com
Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain

PR Ray, S Shiers, JP Caruso, D Tavares-Ferreira… - Brain, 2023 - academic.oup.com
Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …

Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain

HS Shim, C Bae, J Wang, KH Lee… - Molecular …, 2019 - journals.sagepub.com
Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse side effect of many anti-
cancer chemotherapeutic treatments. CIPN often causes neuropathic pain in extremities …

The genetics of neuropathic pain from model organisms to clinical application

M Calvo, AJ Davies, HL Hebert, GA Weir, EJ Chesler… - Neuron, 2019 - cell.com
Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is
both common and disabling, rendering an urgent need for non-addictive, effective new …

Pharmacological target-focused transcriptomic analysis of native vs cultured human and mouse dorsal root ganglia

A Wangzhou, LA McIlvried, C Paige… - Pain, 2020 - journals.lww.com
Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain
processing. They are often studied in vitro as dissociated cell cultures with the assumption …

Differences between dorsal root and trigeminal ganglion nociceptors in mice revealed by translational profiling

S Megat, PR Ray, D Tavares-Ferreira… - Journal of …, 2019 - Soc Neuroscience
Nociceptors located in the trigeminal ganglion (TG) and DRG are the primary sensors of
damaging or potentially damaging stimuli for the head and body, respectively, and are key …

Type I interferons act directly on nociceptors to produce pain sensitization: implications for viral infection-induced pain

P Barragán-Iglesias, Ú Franco-Enzástiga… - Journal of …, 2020 - Soc Neuroscience
One of the first signs of viral infection is body-wide aches and pain. Although this type of pain
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …

Getting in touch with mechanical pain mechanisms

RZ Hill, DM Bautista - Trends in Neurosciences, 2020 - cell.com
The peripheral somatosensory system bestows mammals with a diverse repertoire of
sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and …