How do sensory neurons sense danger signals?
Sensory neurons are activated by physical and chemical stimuli, eliciting sensations such as
temperature, touch, pain, and itch. From an evolutionary perspective, sensing danger is …
temperature, touch, pain, and itch. From an evolutionary perspective, sensing danger is …
Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain
SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
[HTML][HTML] Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury
Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …
information through differences in cell size, myelination, and the expression of distinct …
RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain
Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …
Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain
HS Shim, C Bae, J Wang, KH Lee… - Molecular …, 2019 - journals.sagepub.com
Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse side effect of many anti-
cancer chemotherapeutic treatments. CIPN often causes neuropathic pain in extremities …
cancer chemotherapeutic treatments. CIPN often causes neuropathic pain in extremities …
The genetics of neuropathic pain from model organisms to clinical application
Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is
both common and disabling, rendering an urgent need for non-addictive, effective new …
both common and disabling, rendering an urgent need for non-addictive, effective new …
Pharmacological target-focused transcriptomic analysis of native vs cultured human and mouse dorsal root ganglia
A Wangzhou, LA McIlvried, C Paige… - Pain, 2020 - journals.lww.com
Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain
processing. They are often studied in vitro as dissociated cell cultures with the assumption …
processing. They are often studied in vitro as dissociated cell cultures with the assumption …
Differences between dorsal root and trigeminal ganglion nociceptors in mice revealed by translational profiling
S Megat, PR Ray, D Tavares-Ferreira… - Journal of …, 2019 - Soc Neuroscience
Nociceptors located in the trigeminal ganglion (TG) and DRG are the primary sensors of
damaging or potentially damaging stimuli for the head and body, respectively, and are key …
damaging or potentially damaging stimuli for the head and body, respectively, and are key …
Type I interferons act directly on nociceptors to produce pain sensitization: implications for viral infection-induced pain
P Barragán-Iglesias, Ú Franco-Enzástiga… - Journal of …, 2020 - Soc Neuroscience
One of the first signs of viral infection is body-wide aches and pain. Although this type of pain
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …
Getting in touch with mechanical pain mechanisms
RZ Hill, DM Bautista - Trends in Neurosciences, 2020 - cell.com
The peripheral somatosensory system bestows mammals with a diverse repertoire of
sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and …
sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and …