Annexin-A1 (ANXA1) was first discovered in the early 1980's as a protein, which mediates
(some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 …

Formyl peptide receptors (FPRs), which are seven-membrane G-protein coupled receptors,
recognize chemotactic signals to protect hosts from pathogenic infections and mediate …

Inflammation and abnormal metabolism play important roles in the pathogenesis of diabetic
nephropathy (DN). Annexin A1 (ANXA1) contributes to inflammation resolution and …

Since failed resolution of inflammation is a major contributor to the progression of diabetic
nephropathy, identifying endogenously generated molecules that promote the physiological …

Background and Purpose There are no medications currently available to treat metabolic
inflammation. Bruton's tyrosine kinase (BTK) is highly expressed in monocytes and …

Dyslipidemia is an emerging mechanism in microvascular complications in T2D. Elucidating
the molecular pathomechanisms may pinpoint potential lipid-centric treatments …

Atherosclerosis, a silent chronic vascular pathology, is the cause of the majority of
cardiovascular ischaemic events. Atherosclerosis is characterized by a series of deleterious …

Insulin resistance (IR) is a complex pathological condition central to metabolic diseases
such as type 2 diabetes mellitus (T2DM), cardiovascular disease, non-alcoholic fatty liver …

With the deepening of research, proteomics has developed into a science covering the study
of all the structural and functional characteristics of proteins and the dynamic change rules …

Background Damage to the cerebral vasculature can lead to vascular contributions to
cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to …