Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

Communities of microorganisms (microbiota) are present in all habitats on Earth and are
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …

Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …

Staphylococcus aureus is suspected to fuel disease activity in cutaneous T-cell lymphomas.
In this study, we investigate the effect of a recombinant, antibacterial protein, endolysin (XZ …

Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma
(CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to …

Our skin is home to a diverse community of commensal microorganisms integral to
cutaneous function. However, microbial dysbiosis and barrier perturbation increase the risk …

Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95
million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant …

Cutaneous T-cell lymphoma is characterized by malignant T cells proliferating in a unique
tumor microenvironment dominated by keratinocytes (KCs). Skin colonization and infection …

Streptococcus suis (S. suis) is a swine pathogen that can cause sepsis, meningitis,
endocarditis, and other infectious diseases; it is also a zoonotic pathogen that has caused a …