The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …

The coordinated regulation between cellular glucose uptake and endogenous glucose
production is indispensable for the maintenance of constant blood glucose concentrations …

TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

T-cell acute lymphoblastic leukemia (T-ALL) is characterized as a high-risk stratified disease
associated with frequent relapse, chemotherapy resistance, and a poorer prognostic outlook …

Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …

Abstract Constitutive phosphatidylinositol 3-kinase (PI3K)-AKT activation has a causal role
in adult T-cell leukaemia-lymphoma (ATLL) and other cancers. ATLL cells do not harbour …

Background Alzheimer disease (AD) and other tauopathies develop cerebral intracellular
inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence …

SH3 and multiple ankyrin repeat domains 3 (SHANK3) haploinsufficiency is causative for the
neurological features of Phelan-McDermid syndrome (PMDS), including a high risk of autism …

Transcription by RNA polymerase III (pol III) is responsible for~ 15% of total cellular
transcription through the generation of small structured RNAs such as tRNA and 5S RNA …