[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
Molecular pathophysiology of congenital long QT syndrome
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …
the fundamental cellular electrical event in the heart. The concerted function of these …
Cardiac ventricular repolarization reserve: a principle for understanding drug‐related proarrhythmic risk
Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …
cardiac compounds and may lead to the development of life‐threatening Torsades de …
Molecular determinants of cardiac transient outward potassium current (Ito) expression and regulation
N Niwa, JM Nerbonne - Journal of molecular and cellular cardiology, 2010 - Elsevier
Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …
Sex differences in cardiac electrophysiology and clinical arrhythmias: epidemiology, therapeutics, and mechanisms
Sex differences in cardiac electrophysiological properties and arrhythmias are evident in
epidemiologic and investigative studies as well as in daily patient care. At the …
epidemiologic and investigative studies as well as in daily patient care. At the …
Sex differences in the mechanisms underlying long QT syndrome
G Salama, GCL Bett - American Journal of Physiology …, 2014 - journals.physiology.org
Sexual dimorphism is a well-established phenomenon, but its degree varies tremendously
among species. Since the early days of Einthoven's development of the three-lead …
among species. Since the early days of Einthoven's development of the three-lead …
Acute effects of oestrogen on the guinea pig and human IKr channels and drug‐induced prolongation of cardiac repolarization
J Kurokawa, M Tamagawa, N Harada… - The Journal of …, 2008 - Wiley Online Library
Female gender is a risk factor for drug‐induced arrhythmias associated with QT
prolongation, which results mostly from blockade of the human ether‐a‐go‐go‐related gene …
prolongation, which results mostly from blockade of the human ether‐a‐go‐go‐related gene …
Estrogen contributes to gender differences in mouse ventricular repolarization
T Saito, A Ciobotaru, JC Bopassa, L Toro… - Circulation …, 2009 - Am Heart Assoc
Rationale: Fast-transient outward K+ (I to, f) and ultrarapid delayed rectifier K+ currents (IK,
slow, also known as I Kur) contribute to mouse cardiac repolarization. Gender studies on …
slow, also known as I Kur) contribute to mouse cardiac repolarization. Gender studies on …
Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic …
The association between physiologic levels of sex hormones and QT-interval duration in
humans was evaluated using data from 727 men enrolled in the Third National Health and …
humans was evaluated using data from 727 men enrolled in the Third National Health and …