[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

[HTML][HTML] hERG K+ channels: structure, function, and clinical significance

JI Vandenberg, MD Perry, MJ Perrin… - Physiological …, 2012 - journals.physiology.org
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Molecular pathophysiology of congenital long QT syndrome

MS Bohnen, G Peng, SH Robey… - Physiological …, 2017 - journals.physiology.org
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Cardiac ventricular repolarization reserve: a principle for understanding drug‐related proarrhythmic risk

A Varró, I Baczkó - British journal of pharmacology, 2011 - Wiley Online Library
Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …

Molecular determinants of cardiac transient outward potassium current (Ito) expression and regulation

N Niwa, JM Nerbonne - Journal of molecular and cellular cardiology, 2010 - Elsevier
Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …

Sex differences in cardiac electrophysiology and clinical arrhythmias: epidemiology, therapeutics, and mechanisms

R Tadros, AT Ton, C Fiset, S Nattel - Canadian Journal of Cardiology, 2014 - Elsevier
Sex differences in cardiac electrophysiological properties and arrhythmias are evident in
epidemiologic and investigative studies as well as in daily patient care. At the …

Sex differences in the mechanisms underlying long QT syndrome

G Salama, GCL Bett - American Journal of Physiology …, 2014 - journals.physiology.org
Sexual dimorphism is a well-established phenomenon, but its degree varies tremendously
among species. Since the early days of Einthoven's development of the three-lead …

Acute effects of oestrogen on the guinea pig and human IKr channels and drug‐induced prolongation of cardiac repolarization

J Kurokawa, M Tamagawa, N Harada… - The Journal of …, 2008 - Wiley Online Library
Female gender is a risk factor for drug‐induced arrhythmias associated with QT
prolongation, which results mostly from blockade of the human ether‐a‐go‐go‐related gene …

Estrogen contributes to gender differences in mouse ventricular repolarization

T Saito, A Ciobotaru, JC Bopassa, L Toro… - Circulation …, 2009 - Am Heart Assoc
Rationale: Fast-transient outward K+ (I to, f) and ultrarapid delayed rectifier K+ currents (IK,
slow, also known as I Kur) contribute to mouse cardiac repolarization. Gender studies on …

Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic …

Y Zhang, P Ouyang, WS Post, D Dalal… - American journal of …, 2011 - academic.oup.com
The association between physiologic levels of sex hormones and QT-interval duration in
humans was evaluated using data from 727 men enrolled in the Third National Health and …