Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Autophagy is a critical cellular process that generally protects cells and organisms from
stressors such as nutrient deprivation. In addition to its role in normal physiology, autophagy …

Abstract Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates
the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process …

Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

The balance between cell death and survival is a critical parameter in the regulation of cells
and the maintenance of homeostasis in vivo. Three major mechanisms for cell death have …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Macroautophagy (referred to here as autophagy) degrades and recycles cytoplasmic
constituents to sustain cellular and mammalian metabolism and survival during starvation …

Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …

Autophagy has been shown to be elevated in pancreatic ductal adenocarcinoma (PDAC),
and its role in promoting established tumor growth has made it a promising therapeutic …