Structural evolution of an immune evasion determinant shapes pathogen host tropism

AL Marcinkiewicz, K Brangulis… - Proceedings of the …, 2023 - National Acad Sciences
Modern infectious disease outbreaks often involve changes in host tropism, the preferential
adaptation of pathogens to specific hosts. The Lyme disease-causing bacterium Borrelia …

[HTML][HTML] Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease–and relapsing fever–causing spirochetes

S Roy, CE Booth, AD Powell-Pierce, AM Schulz… - Journal of Biological …, 2023 - ASBMB
Borrelial pathogens are vector-borne etiological agents known to cause Lyme disease,
relapsing fever, and Borrelia miyamotoi disease. These spirochetes each encode several …

Lizards and the enzootic cycle of Borrelia burgdorferi sensu lato

TA Nowak, RL Burke, MA Diuk‐Wasser… - Molecular …, 2024 - Wiley Online Library
Emerging and re‐emerging pathogens often stem from zoonotic origins, cycling between
humans and animals, and are frequently vectored and maintained by hematophagous …

[HTML][HTML] Outer surface protein E (OspE) mediates Borrelia burgdorferi sensu stricto strain-specific complement evasion in the eastern fence lizard, Sceloporus …

TA Nowak, LA Lown, AL Marcinkiewicz, V Sürth… - Ticks and Tick-borne …, 2023 - Elsevier
Abstract In North America, Lyme disease is primarily caused by the spirochetal bacterium
Borrelia burgdorferi sensu stricto (Bb), which is transmitted between multiple vertebrate …

[HTML][HTML] Differential Resistance of Borrelia burgdorferi Clones to Human Serum-Mediated Killing Does Not Correspond to Their Predicted Invasiveness

P Pearson, C Rich, EL Siegel, D Brisson, SM Rich - Pathogens, 2023 - mdpi.com
Reservoir host associations have been observed among and within Borrelia genospecies,
and host complement-mediated killing is a major determinant in these interactions. In North …

Unprecedented genetic variability of PFam54 paralogs among Eurasian Lyme borreliosis‐causing spirochetes

J Wülbern, L Windorfer, K Sato, M Nakao… - Ecology and …, 2024 - Wiley Online Library
Lyme borreliosis (LB) is the most common vector‐borne disease in the Northern
Hemisphere caused by spirochetes belonging to the Borrelia burgdorferi sensu lato (Bb sl) …

[HTML][HTML] Conformational dynamics of C1r inhibitor proteins from Lyme disease and relapsing fever spirochetes

S Roy, CE Booth Jr, AD Powell-Pierce, AM Schulz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Borrelial pathogens are vector-borne etiological agents of Lyme disease, relapsing fever,
and Borrelia miyamotoi disease. These spirochetes each encode several surface-localized …

Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism

AL Marcinkiewicz, K Brangulis, AP Dupuis, TM Hart… - bioRxiv, 2022 - biorxiv.org
The preferential adaptation of pathogens to specific hosts, known as host tropism, evolves
through host-pathogen interactions. Transmitted by ticks and maintained primarily in rodents …

[图书][B] Implicating North American Lizards in the Borrelia burgdorferi Sensu Stricto Sylvatic Cycle

TA Nowak - 2024 - search.proquest.com
Borrelia burgdorferi sensu lato (B. burgdorferi sl) spirochetes are the causative agents of
Lyme disease (LD, Lyme borreliosis), the leading cause of tick-borne illness in North …

[PDF][PDF] Charakterisierung der humoralen Immunantwort von Hunden nach Impfung gegen die Lyme-Borreliose anhand zwei verschiedener Impfstrategien

CK Wilczek - 2023 - edoc.ub.uni-muenchen.de
Die Lyme-Borreliose (LB) gilt als die häufigste, von Zecken übertragene Krankheit der
nördlichen Hemisphäre (WU et al., 2011). Bei den Erregern dieser Erkrankung handelt es …