Imaging and photodynamic therapy: mechanisms, monitoring, and optimization

JP Celli, BQ Spring, I Rizvi, CL Evans… - Chemical …, 2010 - ACS Publications
The purpose of this review is to present the current state of the role of imaging in
photodynamic therapy (PDT). For the reader to fully appreciate the context of the discussions …

Age-related macular degeneration

LS Lim, P Mitchell, JM Seddon, FG Holz, TY Wong - The Lancet, 2012 - thelancet.com
Age-related macular degeneration is a major cause of blindness worldwide. With ageing
populations in many countries, more than 20% might have the disorder. Advanced age …

Development of ranibizumab, an anti–vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration

N Ferrara, L Damico, N Shams, H Lowman, R Kim - Retina, 2006 - journals.lww.com
Background: Angiogenesis is a key aspect of the wet form of age-related neovascular
(AMD), the leading cause of blindness in the elderly population. Substantial evidence …

Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials …

Treatment of Age-Related Macular … - Archives of …, 1999 - jamanetwork.com
Objective To determine if photodynamic therapy with verteporfin (Visudyne; CIBA Vision
Corp, Duluth, Ga) can safely reduce the risk of vision loss in patients with subfoveal …

Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration

U Schmidt-Erfurth, T Hasan - Survey of ophthalmology, 2000 - Elsevier
Age-related macular degeneration, especially the neovascular form of the disease, is the
leading cause of blindness in elderly people in developed countries. Thermal …

Prevention of experimental choroidal neovascularization with intravitreal anti–vascular endothelial growth factor antibody fragment

MG Krzystolik, MA Afshari, AP Adamis… - Archives of …, 2002 - jamanetwork.com
Objective To evaluate the safety and efficacy of intravitreal injections of an antigen-binding
fragment of a recombinant humanized monoclonal antibody directed toward vascular …

Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions …

VIPTS Group1A - American journal of ophthalmology, 2001 - Elsevier
PURPOSE: To determine if photodynamic therapy with verteporfin (Visudyne; Novartis AG,
Bülach, Switzerland), termed verteporfin therapy, can safely reduce the risk of vision loss …

Spatially resolved cellular responses to singlet oxygen

RW Redmond, IE Kochevar - Photochemistry and photobiology, 2006 - BioOne
Abstract Singlet oxygen (1O2) is unique amongst reactive oxygen species formed in cells in
that it is an excited state molecule with an inherent upper lifetime of 4 μs in water. Whether …

Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease?

A Laude, PD Cackett, EN Vithana, IY Yeo… - Progress in retinal and …, 2010 - Elsevier
Neovascular age-related macular degeneration (nAMD) is the commonest cause of severe
visual impairment in older adults in Caucasian white populations. Polypoidal choroidal …

A pH-activatable and aniline-substituted photosensitizer for near-infrared cancer theranostics

J Tian, J Zhou, Z Shen, L Ding, JS Yu, H Ju - Chemical Science, 2015 - pubs.rsc.org
This work reports a newly designed pH-activatable and aniline-substituted aza-boron-
dipyrromethene as a trifunctional photosensitizer to achieve highly selective tumor imaging …