Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity

S Dubey, PA Bhosle - Medicinal Chemistry Research, 2015 - Springer
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …

Pyridazin-3(2H)-ones: the versatile pharmacophore of medicinal significance

R Bansal, S Thota - Medicinal Chemistry Research, 2013 - Springer
Abstract Pyridazin-3 (2 H)-one derivatives have attracted the attention of medicinal chemists
during the last decade due to their diverse pharmacological activities. Easy functionalization …

Synthesis and analgesic and anti-inflammatory activities 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal) hydrazone derivatives

M Gökçe, S Utku, E Küpeli - European journal of medicinal chemistry, 2009 - Elsevier
In this study new 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted benzal)
hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The …

Synthesis, analgesic, and anti-inflammatory activities of [6-(3, 5-dimethyl-4-chloropyrazole-1-yl)-3 (2H)-pyridazinon-2-yl] acetamides

M Süküroglu, BÇ Ergün, S ünlü, MF Sahin… - Archives of pharmacal …, 2005 - Springer
A series of structurally diverse amide derivatives of [6-(3, 5-dimethyl-4-chloro-pyrazole-1-yl)-
3 (2H)-pyridazinone-2-yl] acetic acid were prepared and tested for their in vivo analgesic …

A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies

AB Özçelik, Z Özdemir, S Sari, S Utku, M Uysal - Pharmacological Reports, 2019 - Elsevier
Background The pyridazinone nucleus has been incorporated into a wide variety of
therapeutically interesting molecules to transform them into better drugs …

General study of pyridazine compounds against cyclooxygenase enzyme and their relation with analgesic, anti-inflammatory and anti-arthritic activities

M Asif - Chronicles of Young Scientists, 2010 - go.gale.com
There is increased focus on developed non-steroidal anti-inflammatory drugs (NSAIDs)
containing a pyridazine nucleus. The NSAIDs are one of the most commonly used …

Synthesis of new mannich bases of arylpyridazinones as analgesic and anti-inflammatory agents

M Goekce, G Bakır, MF Şahin, E Kuepeli… - …, 2005 - thieme-connect.com
A series of 2-[[4-(substituted-phenyl/benzyl)-1-piperazinyl] methyl]-6-(4-methoxyphenyl)-3
(2H) pyridazinone derivatives was prepared and examined for analgesic and anti …

Synthesis of novel 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(substituted/-nonsubstituted benzal) hydrazone derivatives and acetylcholinesterase and …

S Utku, M Gökçe, İ Orhan, MF Şahin - Arzneimittelforschung, 2011 - thieme-connect.com
In this study thirteen 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(substituted/-
nonsubstituted benzal) hydrazone V derivatives were synthesized as acetylcholinesterase …

Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities

S BAYTAŞ, N Inceler, KF Mavaneh… - Turkish Journal of …, 2012 - journals.tubitak.gov.tr
Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo
analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and …

Recent advances in anti-inflammatory potential of pyridazinone derivatives

M Saini, DK Mehta, R Das… - Mini Reviews in Medicinal …, 2016 - ingentaconnect.com
Pyridazinone and its derivatives have various ranges of biological and pharmacological
activities including anti-inflammatory, antifeedant, anticonvulsant, antidiabetic, herbicidal …