The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …

Sirolimus (rapamycin) is a macrocyclic lactone isolated from a strain of Streptomyces
hygroscopicus that inhibits the mammalian target of rapamycin (mTOR)-mediated signal …

Understanding individual susceptibility to drug-induced cardiotoxicity is key to improving
patient safety and preventing drug attrition. Human induced pluripotent stem cells (hiPSCs) …

We here investigate the effects of two exercise modalities (endurance treadmill training-TM
and voluntary free-wheel activity-FW) on the brain cortex and cerebellum mitochondrial …

Doxorubicin (DOX) is an anti-cancer agent whose clinical usage results in a cumulative and
dose-dependent cardiotoxicity. We have previously shown that exercise performed prior to …

Skeletal muscle is a highly specialized tissue that contains two distinct mitochondria
subpopulations, the subsarcolemmal (SS) and the intermyofibrillar (IMF) mitochondria …

The use of DOX (doxorubicin), an antibiotic used in oncological treatments, is limited by a
dose-related cardiotoxicity against which acute exercise is protective. However, the …

Mitochondrial toxicity has been shown to contribute to a variety of organ toxicities such as
liver, cardiac, and kidney. In the past decades, two high-throughput applicable screening …

Background Existing measures of frailty developed in community dwelling older adults may
misclassify frailty in lung transplant candidates. We aimed to develop a novel frailty scale for …

Background Lung transplantation and related medications are associated with
pathobiological changes that can induce frailty, a state of decreased physiological reserve …