Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play
important roles in cancer development and progression, being deeply implicated in …

Integrins contribute to cancer progression and aggressiveness by activating intracellular
signal transduction pathways and transducing mechanical tension forces. Remarkably …

Multiple cancer types have limited targeted therapeutic options, in part due to incomplete
understanding of the molecular processes underlying tumorigenesis and significant intra …

Cell adhesion to the extracellular matrix (ECM) is important in a variety of physiological and
pathologic processes, including development, tumor invasion, and metastasis. Integrin …

Cancer cell mutations can be identified by genomic and transcriptomic techniques.
However, they are not sufficient to understand the full complexity of cancer heterogeneity …

Simple Summary Osimertinib is a third-generation EGFR tyrosine kinase inhibitor and the
standard of care therapy for non-small cell lung cancer patients harboring EGFR-activating …

Epidermal growth factor receptor (EGFR) targeted therapies have shown limited efficacy in
head and neck squamous cell carcinoma (HNSCC) patients despite its overexpression …

Anoikis, a mode of programmed cell death, is essential for normal development and
homeostasis in the organism and plays an important role in the onset and progression of …

Understanding the cellular processes is central to comprehend disease conditions and is
also true for cancer research. Proteomic studies provide significant insight into cancer …