[HTML][HTML] Functional and clinical characteristics of focal adhesion kinases in cancer progression
Z Zhang, J Li, S Jiao, G Han, J Zhu… - Frontiers in Cell and …, 2022 - frontiersin.org
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …
Molecular pathway activation–new type of biomarkers for tumor morphology and personalized selection of target drugs
Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play
important roles in cancer development and progression, being deeply implicated in …
important roles in cancer development and progression, being deeply implicated in …
[HTML][HTML] Role of integrins in resistance to therapies targeting growth factor receptors in cancer
E Cruz da Silva, M Dontenwill, L Choulier, M Lehmann - Cancers, 2019 - mdpi.com
Integrins contribute to cancer progression and aggressiveness by activating intracellular
signal transduction pathways and transducing mechanical tension forces. Remarkably …
signal transduction pathways and transducing mechanical tension forces. Remarkably …
[HTML][HTML] High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders
Multiple cancer types have limited targeted therapeutic options, in part due to incomplete
understanding of the molecular processes underlying tumorigenesis and significant intra …
understanding of the molecular processes underlying tumorigenesis and significant intra …
Crosstalk between Epidermal Growth Factor Receptors (EGFR) and integrins in resistance to EGFR tyrosine kinase inhibitors (TKIs) in solid tumors
S Javadi, M Zhiani, MA Mousavi, M Fathi - European Journal of Cell Biology, 2020 - Elsevier
Cell adhesion to the extracellular matrix (ECM) is important in a variety of physiological and
pathologic processes, including development, tumor invasion, and metastasis. Integrin …
pathologic processes, including development, tumor invasion, and metastasis. Integrin …
Investigation of cancer drug resistance mechanisms by phosphoproteomics
Cancer cell mutations can be identified by genomic and transcriptomic techniques.
However, they are not sufficient to understand the full complexity of cancer heterogeneity …
However, they are not sufficient to understand the full complexity of cancer heterogeneity …
[HTML][HTML] Ras-related protein Rab-32 and thrombospondin 1 confer resistance to the EGFR tyrosine kinase inhibitor osimertinib by activating focal adhesion kinase in …
Simple Summary Osimertinib is a third-generation EGFR tyrosine kinase inhibitor and the
standard of care therapy for non-small cell lung cancer patients harboring EGFR-activating …
standard of care therapy for non-small cell lung cancer patients harboring EGFR-activating …
[HTML][HTML] MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma
Epidermal growth factor receptor (EGFR) targeted therapies have shown limited efficacy in
head and neck squamous cell carcinoma (HNSCC) patients despite its overexpression …
head and neck squamous cell carcinoma (HNSCC) patients despite its overexpression …
[HTML][HTML] Identification of a new anoikis-related gene signature for prognostic significance in head and neck squamous carcinomas
Z Wei, C Zhou, Y Shen, H Deng, Z Shen - Medicine, 2023 - journals.lww.com
Anoikis, a mode of programmed cell death, is essential for normal development and
homeostasis in the organism and plays an important role in the onset and progression of …
homeostasis in the organism and plays an important role in the onset and progression of …
[HTML][HTML] Phosphoproteomic strategies in cancer research: a minireview
Understanding the cellular processes is central to comprehend disease conditions and is
also true for cancer research. Proteomic studies provide significant insight into cancer …
also true for cancer research. Proteomic studies provide significant insight into cancer …