Breast cancer is one of the most common malignancies among women throughout the world
and is the major cause of most cancer-related deaths. Several explanations account for the …

It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Tumor-associated macrophages have emerged as crucial factors for metastases. Microglia
are indispensable components of the brain microenvironment and play vital roles in brain …

It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the …

The epithelial–mesenchymal transition (EMT) confers mesenchymal properties on epithelial
cells and has been closely associated with the acquisition of aggressive traits by carcinoma …

Forced overexpression and/or downregulation of proteins regulating epithelial-to-
mesenchymal transition (EMT) has been reported to alter metastasis by changing migration …

Retaining the delicate balance in cell signaling activity is a prerequisite for the maintenance
of physiological tissue homeostasis. Transforming growth factor‐beta (TGFβ) signaling is an …

Although major progress has been achieved in treating breast cancer patients, metastatic
breast cancer still remains a deadly disease. A full understanding of the process of systemic …

The prerequisite function of vimentin for the epithelial–mesenchymal transition (EMT) is not
clearly elucidated yet. Here, we show that vimentin phosphorylated by PLK1, triggers TGF-β …