Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules
that constitute a newly described killing mechanism in innate immune defense. Previous …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

The protein kinase C (PKC) family consists of 10 related serine/threonine protein kinases
some of which are critical regulators of cell proliferation, survival and cell death. While early …

Simple Summary The protein kinase C (PKC) family belongs to serine-threonine kinases
and consists of several subtypes. Increasing evidence suggests that PKCs are critical …

Activation of protein kinase C (PKC) by phorbol esters or diacylglycerol mimetics induces
apoptosis in androgen-dependent prostate cancer cells, an effect that involves both the …

Abstract Ingenol 3-angelate (I3A) is one of the active ingredients in Euphorbia peplus, which
has been used in traditional medicine. Here, we report the initial characterization of I3A as a …