Protein kinase C, an elusive therapeutic target?
D Mochly-Rosen, K Das, KV Grimes - Nature reviews Drug discovery, 2012 - nature.com
Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …
Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression
N Isakov - Seminars in cancer biology, 2018 - Elsevier
The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …
members that are critical regulators of numerous cellular functions, including cell cycle and …
A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus
FH Pilsczek, D Salina, KKH Poon, C Fahey… - The Journal of …, 2010 - journals.aai.org
Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules
that constitute a newly described killing mechanism in innate immune defense. Previous …
that constitute a newly described killing mechanism in innate immune defense. Previous …
Protein kinase C and cancer: what we know and what we do not
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …
Protein kinase C and other diacylglycerol effectors in cancer
EM Griner, MG Kazanietz - Nature Reviews Cancer, 2007 - nature.com
Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …
partial understanding of how this family of serine/threonine kinases is involved in tumour …
C1 domains exposed: from diacylglycerol binding to protein–protein interactions
F Colón-González, MG Kazanietz - … et Biophysica Acta (BBA)-Molecular and …, 2006 - Elsevier
C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …
[HTML][HTML] Protein kinase C isoforms: Multi-functional regulators of cell life and death
ME Reyland - Frontiers in bioscience (Landmark edition), 2009 - ncbi.nlm.nih.gov
The protein kinase C (PKC) family consists of 10 related serine/threonine protein kinases
some of which are critical regulators of cell proliferation, survival and cell death. While early …
some of which are critical regulators of cell proliferation, survival and cell death. While early …
Targeting protein kinase C for cancer therapy
S He, Q Li, Q Huang, J Cheng - Cancers, 2022 - mdpi.com
Simple Summary The protein kinase C (PKC) family belongs to serine-threonine kinases
and consists of several subtypes. Increasing evidence suggests that PKCs are critical …
and consists of several subtypes. Increasing evidence suggests that PKCs are critical …
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway
Y Tanaka, MV Gavrielides, Y Mitsuuchi, T Fujii… - Journal of Biological …, 2003 - ASBMB
Activation of protein kinase C (PKC) by phorbol esters or diacylglycerol mimetics induces
apoptosis in androgen-dependent prostate cancer cells, an effect that involves both the …
apoptosis in androgen-dependent prostate cancer cells, an effect that involves both the …
Characterization of the interaction of ingenol 3-angelate with protein kinase C
N Kedei, DJ Lundberg, A Toth, P Welburn, SH Garfield… - Cancer research, 2004 - AACR
Abstract Ingenol 3-angelate (I3A) is one of the active ingredients in Euphorbia peplus, which
has been used in traditional medicine. Here, we report the initial characterization of I3A as a …
has been used in traditional medicine. Here, we report the initial characterization of I3A as a …