Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Diffusion MRI (dMRI) has proven to be a useful imaging approach for both clinical diagnosis
and research investigating the microstructures of nervous tissues, and it has helped us to …

The number of Americans over the age of 65 is projected to more than double in the next
forty years, increasing from 40.2 million in 2010 to 88.5 million in 2050. 1 It will become …

Objective Conventional magnetic resonance imaging (MRI) of the multiple sclerosis spinal
cord is limited by low specificity regarding the underlying pathological processes, and new …

Astrocytes are fundamental for homoeostasis, defence and regeneration of the central
nervous system. Loss of astroglial function and astroglial reactivity contributes to the aging of …

Mild traumatic brain injury (mTBI) accounts for approximately 80% of all TBI cases and is a
growing source of morbidity and mortality worldwide. To improve the management of …

Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Aging is accompanied by many changes in brain and contributes to progressive cognitive
decline. In contrast to pathological changes in brain, normal aging brain changes have …

During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …