Staging of Alzheimer's disease: past, present, and future perspectives
For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …
disease, the tail end of a pathophysiological process that lasts approximately two decades …
Positron emission tomography in multiple sclerosis—straight to the target
Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …
(MS), the major challenge ahead is the development of treatments to prevent or delay the …
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …
arise from molecular perturbations or connectome miswiring. The unique and shared …
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration
In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogeneous
across patients. A high heterogeneity in remyelination may also exist across lesions within …
across patients. A high heterogeneity in remyelination may also exist across lesions within …
[HTML][HTML] χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain
Obtaining a histological fingerprint from the in-vivo brain has been a long-standing target of
magnetic resonance imaging (MRI). In particular, non-invasive imaging of iron and myelin …
magnetic resonance imaging (MRI). In particular, non-invasive imaging of iron and myelin …
Mapping myelin in white matter with T1-weighted/T2-weighted maps: discrepancy with histology and other myelin MRI measures
The ratio of T1-weighted/T2-weighted magnetic resonance images (T1w/T2w MRI) has been
successfully applied at the cortical level since 2011 and is now one of the most used myelin …
successfully applied at the cortical level since 2011 and is now one of the most used myelin …
Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …
with water between the wraps. The measurement of damage to the myelin sheaths, the …
How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …
scientific and medical advances, clinically effective regenerative therapies including stem …
Macromolecular proton fraction as a myelin biomarker: principles, validation, and applications
AA Kisel, AV Naumova, VL Yarnykh - Frontiers in neuroscience, 2022 - frontiersin.org
Macromolecular proton fraction (MPF) is a quantitative MRI parameter describing the
magnetization transfer (MT) effect and defined as a relative amount of protons bound to …
magnetization transfer (MT) effect and defined as a relative amount of protons bound to …
An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression
P Ananthavarathan, N Sahi… - Expert Review of …, 2024 - Taylor & Francis
Introduction While magnetic resonance imaging (MRI) is established in diagnosing and
monitoring disease activity in multiple sclerosis (MS), its utility in predicting and monitoring …
monitoring disease activity in multiple sclerosis (MS), its utility in predicting and monitoring …