Staging of Alzheimer's disease: past, present, and future perspectives

J Therriault, ER Zimmer, AL Benedet… - Trends in molecular …, 2022 - cell.com
For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …

Positron emission tomography in multiple sclerosis—straight to the target

B Bodini, M Tonietto, L Airas, B Stankoff - Nature reviews Neurology, 2021 - nature.com
Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

JY Hansen, G Shafiei, JW Vogel, K Smart… - Nature …, 2022 - nature.com
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration

M Tonietto, E Poirion, A Lazzarotto, V Ricigliano… - Brain, 2023 - academic.oup.com
In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogeneous
across patients. A high heterogeneity in remyelination may also exist across lesions within …

[HTML][HTML] χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain

HG Shin, J Lee, YH Yun, SH Yoo, J Jang, SH Oh… - Neuroimage, 2021 - Elsevier
Obtaining a histological fingerprint from the in-vivo brain has been a long-standing target of
magnetic resonance imaging (MRI). In particular, non-invasive imaging of iron and myelin …

Mapping myelin in white matter with T1-weighted/T2-weighted maps: discrepancy with histology and other myelin MRI measures

S Sandrone, M Aiello, C Cavaliere… - Brain Structure and …, 2023 - Springer
The ratio of T1-weighted/T2-weighted magnetic resonance images (T1w/T2w MRI) has been
successfully applied at the cortical level since 2011 and is now one of the most used myelin …

Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

CWJ van der Weijden, E Biondetti, IW Gutmann… - Brain, 2023 - academic.oup.com
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?

N Hejrati, R Wong, M Khazaei… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …

Macromolecular proton fraction as a myelin biomarker: principles, validation, and applications

AA Kisel, AV Naumova, VL Yarnykh - Frontiers in neuroscience, 2022 - frontiersin.org
Macromolecular proton fraction (MPF) is a quantitative MRI parameter describing the
magnetization transfer (MT) effect and defined as a relative amount of protons bound to …

An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression

P Ananthavarathan, N Sahi… - Expert Review of …, 2024 - Taylor & Francis
Introduction While magnetic resonance imaging (MRI) is established in diagnosing and
monitoring disease activity in multiple sclerosis (MS), its utility in predicting and monitoring …