Due to the massive data sets available for drug candidates, modern drug discovery has
advanced to the big data era. Central to this shift is the development of artificial intelligence …

Histone deacetylase inhibitors are a large group of diverse molecules intrinsically able to
inhibit cell proliferation in various cancer cell lines. Their apoptotic effects have been linked …

Novel treatment regimens are required for castration-resistant prostate cancers (CRPCs)
that become unresponsive to standard treatments, such as docetaxel and enzalutamide …

For the Alzheimer's disease (AD) with complex pathogenesis, single target drugs represent
one of the most effective therapeutic strategies in clinical. However, the traditional concept of …

Histones undergo extensive posttranslational modifications that affect gene expression.
Acetylation is a key histone modification that is primarily regulated by two enzymes, one of …

In the landscape of epigenetic regulation, histone deacetylase 3 (HDAC3) has emerged as a
prominent therapeutic target for the design and development of candidate drugs against …

Histone deacetylases (HDACs) as an important family of epigenetic regulatory enzymes are
implicated in the onset and progression of carcinomas. As a result, HDAC inhibition has …

Histone deacetylases 2 (HDAC2), Class I histone deacetylase (HDAC) family, emerged as
an important therapeutic target for the treatment of various cancers. A total of 48 inhibitors of …

Histone methyltransferases are involved in various biological functions, and these
methylation regulating enzymes' abnormal expression or activity has been noted in several …

Hydroxamic acids constitute a unique family of chemicals with multiple biological activities,
because they act as potent and selective inhibitors of a large number of enzymes, such as …