Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

The genetic and molecular basis of ALS is increasingly examined on single-cell resolution.
In the past 2 years, the understanding of the downstream mechanisms of several ALS genes …

A multitude of cellular processes involve biomolecular condensates, which has led to the
suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive
loss of motor neurons, leading to a fatal paralysis. According to whether there is a family …

Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative
diseases. They also represent rare common events in an exceptionally broad landscape of …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via
the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's …

Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale
organization of proteins, RNAs, and membrane-bound organelles into biomolecular …

Stress granules are conserved cytosolic ribonucleoprotein (RNP) compartments that
undergo dynamic assembly and disassembly by phase separation in response to stressful …