Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Improved knowledge of all aspects of adipose biology will be required to counter the
burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the …

Wnts are secreted signaling proteins that regulate developmental processes. Here we show
that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch that governs …

The past twenty years have seen great strides in our understanding of the molecular
regulation of differentiation for a whole host of specific cell types. The development of …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

Adipose tissue is central to the regulation of energy balance. Two functionally different types
of fat are present in mammals: white adipose tissue, the primary site of triglyceride storage …

CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all
contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in …