The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

Implications of the hybrid epithelial/mesenchymal phenotype in metastasis

MK Jolly, M Boareto, B Huang, D Jia, M Lu… - Frontiers in …, 2015 - frontiersin.org
Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

A patient-derived, pan-cancer EMT signature identifies global molecular alterations and immune target enrichment following epithelial-to-mesenchymal transition

MP Mak, P Tong, L Diao, RJ Cardnell, DL Gibbons… - Clinical Cancer …, 2016 - AACR
Purpose: We previously demonstrated the association between epithelial-to-mesenchymal
transition (EMT) and drug response in lung cancer using an EMT signature derived in …

[HTML][HTML] The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy

B Humphries, C Yang - Oncotarget, 2015 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate
protein-coding gene expression post-transcriptionally via base pairing between the 5 …

Epithelial–mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease

MK Jolly, C Ward, MS Eapen, S Myers… - Developmental …, 2018 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) plays key roles during lung development and
many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer …

The regulatory role of microRNAs in EMT and cancer

A Zaravinos - Journal of oncology, 2015 - Wiley Online Library
The epithelial to mesenchymal transition (EMT) is a powerful process in tumor invasion,
metastasis, and tumorigenesis and describes the molecular reprogramming and phenotypic …

Cancer-associated fibroblasts: how do they contribute to metastasis?

MQ Kwa, KM Herum, C Brakebusch - Clinical & experimental metastasis, 2019 - Springer
Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the tumor
microenvironment. They are one of the most prominent cell types in the stroma and produce …

Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

J van Staalduinen, D Baker, P Ten Dijke, H van Dam - Oncogene, 2018 - nature.com
Chemoresistance remains a major complication of cancer treatments. Recent data provide
strong evidence that chemoresistance is linked to epithelial–mesenchymal transition (EMT) …

Smoking, p53 mutation, and lung cancer

DL Gibbons, LA Byers, JM Kurie - Molecular cancer research, 2014 - AACR
This issue marks the 50th anniversary of the release of the US Surgeon General's Report on
Smoking and Health. Perhaps no other singular event has done more to highlight the effects …

Emerging roles of exosomes during epithelial–mesenchymal transition and cancer progression

DW Greening, SK Gopal, RA Mathias, L Liu… - Seminars in cell & …, 2015 - Elsevier
Epithelial–mesenchymal transition (EMT) is a highly conserved process defined by the loss
of epithelial characteristics, and acquisition of the mesenchymal phenotype. In addition to its …