Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Frailty is a clinical syndrome characterized by a reduced physiologic reserve, increased
vulnerability to stressors and an increased risk of adverse outcomes. People with atrial …

Life expectancy has been on the rise for the past few decades, but healthy life expectancy
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …

Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors,
leading to a higher risk of negative health-related outcomes.“Inflammaging”, an age-related …

While the benefits of physical exercise for a healthy aging are well-recognized, a growing
body of evidence shows that sedentary behavior has deleterious health effects …

Background Systemic chronic inflammation has been proposed as an essential mediating
factor in frailty, and several studies tested its relationship with frailty. However, the issue is …

Frailty is a common geriatric syndrome characterized by increased vulnerability and is
associated with adverse clinical events such as falls, hospitalization, and death. Early …

Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against
the microbiota, as well as a conduit for signaling between the microbiota and systemic host …