Adiponectin is the most abundant peptide secreted by adipocytes, being a key component in
the interrelationship between adiposity, insulin resistance and inflammation. Central obesity …

Adipose tissue plays important roles in regulating whole-body energy metabolism through
its storage function in white adipocytes and its dissipating function in brown and beige …

Adipose tissue secretes protein factors that have systemic actions on cardiovascular tissues.
Previous studies have shown that ablation of the adipocyte-secreted protein adiponectin …

Background: Epigenetic factors including DNA methylation contribute to specific patterns of
gene expression. Gene–environment interactions can change the methylation status in the …

As a non-canonical member of cadherin superfamily, T-cadherin was initially described as a
molecule involved in homophilic recognition in the nervous and vascular systems. The …

Adiponectin (Adipo), a multimeric adipocyte-secreted protein abundant in the circulation, is
implicated in cardiovascular protective functions. Recent work documented that Adipo …

Obesity is linked to increased cancer risk. Pathological expansion of adipose tissue impacts
adipocyte function and secretion of hormonal factors regulating tissue homeostasis and …

Aging is defined as a time-dependent functional decline that occurs in many physiological
systems. This decline is the primary risk factor for prominent human pathologies such as …

Gestational diabetes mellitus (GDM), which has an increasing global prevalence,
contributes to the susceptibility to metabolic dysregulation and obesity in the offspring via …

Adipokines are bioactive proteins that mediate proliferation, metabolism, inflammation, and
angiogenesis. Adiponectin is an important adipokine that exerts multiple key functions via its …