Cells respond to viral infections through sensors that detect non-self-molecules, and through
effectors, which can have direct antiviral activities or adapt cell physiology to limit viral …

As obligate intracellular parasites, virus reproduction requires host cell functions. Despite
variations in genome size and configuration, nucleic acid composition, and their repertoire of …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

Although viruses require cellular functions to replicate, their absolute dependence upon the
host translation machinery to produce polypeptides indispensable for their reproduction is …

The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus
species which pose a threat to both human and animal health. Most prominent members …

Rift Valley fever is a mosquito-borne zoonotic disease that affects both ruminants and
humans. The nonstructural (NS) protein, which is a major virulence factor for Rift Valley fever …

β‐transducin repeat‐containing protein (β‐TrCP), one of the well‐characterized F‐box
proteins, acts as a substrate receptor and constitutes an active SCFβ‐TrCP E3 ligase with a …

Bunyaviruses represent the largest group of RNA viruses and are the causative agent of a
variety of febrile and hemorrhagic illnesses. Originally characterized as a single serotype in …

Neddylation is one type of protein post‐translational modification by conjugating a ubiquitin‐
like protein neural precursor cell‐expressed developmentally downregulated protein 8 to …

Abstract β-transducin repeat-containing protein (β-TrCP), one of the best-characterized
substrate recognition components of the SKP1-CUL1-F-box (SCF) E3 ligase, has two distinct …