Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

SM Lagoumtzi, N Chondrogianni - Free Radical Biology and Medicine, 2021 - Elsevier
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Q Xu, Q Fu, Z Li, H Liu, Y Wang, X Lin, R He… - Nature …, 2021 - nature.com
Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …

Potential role of polyphenolic flavonoids as senotherapeutic agents in degenerative diseases and geroprotection

KC Mbara, N Devnarain, PMO Owira - Pharmaceutical Medicine, 2022 - Springer
Cellular senescence, a hallmark of ageing, contributes to tissue or organ dysfunction and
the pathophysiology of diverse age-related diseases (ARD) by various mechanisms …

Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging–from theory to practice

C Luís, AT Maduro, P Pereira, JJ Mendes… - Frontiers in …, 2022 - frontiersin.org
Aging is a natural physiological process, but one that poses major challenges in an
increasingly aging society prone to greater health risks such as diabetes, cardiovascular …

Phytochemical study and in vitro screening focusing on the anti-aging features of various plants of the Greek flora

AD Sklirou, MT Angelopoulou, A Argyropoulou… - Antioxidants, 2021 - mdpi.com
Skin health is heavily affected by ultraviolet irradiation from the sun. In addition, senile skin is
characterized by major changes in the collagen, elastin and in the hyaluronan content …

Targeting therapy-induced senescence as a novel strategy to combat chemotherapy-induced peripheral neuropathy

M Alsalem, A Ellaithy, S Bloukh, M Haddad… - Supportive Care in …, 2024 - Springer
Chemotherapy-induced peripheral neuropathy (CIPN) is a treatment-limiting adverse effect
of anticancer therapy that complicates the lifestyle of many cancer survivors. There is …

Biological Characterization and Quantification of Rambutan (Nephelium lappaceum L.) Peel Extract as a Potential Source of Valuable Minerals and Ellagitannins for …

S Torgbo, P Rugthaworn, U Sukatta, P Sukyai - ACS omega, 2022 - ACS Publications
This study extracted ellagitannins from rambutan peel using the Soxhlet technique. The
extract was further partitioned and fractionated to get extract rich in ellagitannin and …

Review of Nephelium lappaceum and Nephelium ramboutan-ake: A High Potential Supplement

JL Tsong, LPW Goh, JA Gansau, SE How - Molecules, 2021 - mdpi.com
Nephelium lappaceum (N. lappaceum) and Nephelium ramboutan-ake (N. ramboutan-ake)
are tropical fruits that gain popularity worldwide due to their tastiness. Currently, their …

Research progress and trends in metabolomics of fruit trees

J Li, G Yan, X Duan, K Zhang, X Zhang… - Frontiers in Plant …, 2022 - frontiersin.org
Metabolomics is an indispensable part of modern systems biotechnology, applied in the
diseases' diagnosis, pharmacological mechanism, and quality monitoring of crops …

Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking

B Ryu, HM Cho, M Zhang, BW Lee, TP Doan, EJ Park… - Phytochemistry, 2021 - Elsevier
MS/MS-based molecular networking showed differences in the chemical profiles, especially
the terpenoid-coupled-phloroglucinol clusters, of Psidium guajava grown in Jeju Island of …