Opportunities and challenges of translational 3D bioprinting

SV Murphy, P De Coppi, A Atala - Nature biomedical engineering, 2020 - nature.com
Abstract 3D-printed orthopaedic devices and surgical tools, printed maxillofacial implants
and other printed acellular devices have been used in patients. By contrast, bioprinted living …

Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

S Muthu, JV Korpershoek, EJ Novais… - Nature Reviews …, 2023 - nature.com
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis

D D'Amico, M Olmer, AM Fouassier, P Valdés… - Aging cell, 2022 - Wiley Online Library
Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy.
According to the World Health Organization, OA affects over 500 million people and is …

Cell-based tissue engineering strategies used in the clinical repair of articular cartilage

BJ Huang, JC Hu, KA Athanasiou - Biomaterials, 2016 - Elsevier
One of the most important issues facing cartilage tissue engineering is the inability to move
technologies into the clinic. Despite the multitude of current research in the field, it is known …

Tissue engineering and regenerative medicine: history, progress, and challenges

F Berthiaume, TJ Maguire… - Annual review of …, 2011 - annualreviews.org
The past three decades have seen the emergence of an endeavor called tissue engineering
and regenerative medicine in which scientists, engineers, and physicians apply tools from a …

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model

P Occhetta, A Mainardi, E Votta… - Nature biomedical …, 2019 - nature.com
Owing to population aging, the social impact of osteoarthritis (OA)—the most common
musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to …

Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment

LJ Kang, J Yoon, JG Rho, HS Han, S Lee, YS Oh… - Biomaterials, 2021 - Elsevier
Although osteoarthritis (OA) is the most prevalent degenerative joint disease, there is no
effective disease-modifying therapy. We report an empty self-assembled hyaluronic acid …

Stem cell-based tissue engineering with silk biomaterials

Y Wang, HJ Kim, G Vunjak-Novakovic, DL Kaplan - Biomaterials, 2006 - Elsevier
Silks are naturally occurring polymers that have been used clinically as sutures for centuries.
When naturally extruded from insects or worms, silk is composed of a filament core protein …

Biopolymer-based hydrogels for cartilage tissue engineering

B Balakrishnan, R Banerjee - Chemical reviews, 2011 - ACS Publications
Replacement of body parts has been studied for at least 2500 years, when missing teeth
were substituted with artificial teeth engraved from the bones of oxen. 1 Artificial substitutes …

Engineering cartilage tissue

C Chung, JA Burdick - Advanced drug delivery reviews, 2008 - Elsevier
Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage
tissue damaged due to disease or trauma. Since cartilage lacks regenerative capabilities, it …