Mitochondrial MicroRNAs in aging and neurodegenerative diseases
A John, A Kubosumi, PH Reddy - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell
growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis …
growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis …
Mitochondrial (Dys) function in inflammaging: do MitomiRs influence the energetic, oxidative, and inflammatory status of senescent cells?
A relevant feature of aging is chronic low‐grade inflammation, termed inflammaging, a key
process promoting the development of all major age‐related diseases. Senescent cells can …
process promoting the development of all major age‐related diseases. Senescent cells can …
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
Molecular mechanisms of organismal and cell aging remain incompletely understood. We,
therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 …
therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 …
Evidence for the presence and release of BDNF in the neuronal and non‐neuronal structures of the internal anal sphincter
Background Data on the neuromodulatory effects of brain‐derived neurotrophic factor
(BDNF) in the gastrointestinal tract were recently reported, but there are still no data on the …
(BDNF) in the gastrointestinal tract were recently reported, but there are still no data on the …
BDNF rescues aging-associated internal anal sphincter dysfunction
A Singh, S Rattan - American Journal of Physiology …, 2021 - journals.physiology.org
Aging can lead to rectoanal incontinence due to internal anal sphincter (IAS) dysfunction,
which is characterized by a decrease in IAS tone and contractility and an increase in …
which is characterized by a decrease in IAS tone and contractility and an increase in …
miR-21 plays a dual role in tumor formation and cytotoxic response in breast tumors
Simple Summary miR-21 is an oncogenic microRNA that has been associated with breast
tumor growth and metastasis in vitro and is also noted to be upregulated by cytotoxic …
tumor growth and metastasis in vitro and is also noted to be upregulated by cytotoxic …
Gastric emptying abnormalities in diabetes mellitus
RK Goyal - New England Journal of Medicine, 2021 - Mass Medical Soc
Gastric Emptying Abnormalities in Diabetes Persistent gastric emptying problems require
diagnosis and management. Postprandial dyspepsia and impaired plasma glucose …
diagnosis and management. Postprandial dyspepsia and impaired plasma glucose …
BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release
Presently, there are no studies examining the neuromodulatory effects of brain-derived
neurotropic factor (BDNF) on the basal internal anal sphincter (IAS) tone and nonadrenergic …
neurotropic factor (BDNF) on the basal internal anal sphincter (IAS) tone and nonadrenergic …
Novel molecular characterization of colorectal primary tumors based on miRNAs
E Conde, A Pascual, D Prieto-Cuadra, VF Laza… - Cancers, 2019 - mdpi.com
microRNAs (miRNA) expression in colorectal (CR) primary tumours can facilitate a more
precise molecular characterization. We identified and validated a miRNA profile associated …
precise molecular characterization. We identified and validated a miRNA profile associated …
Cell therapy for anal sphincter incontinence: where do we stand?
Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life
and induces high costs for the society. Surgery, considered as the best curative option …
and induces high costs for the society. Surgery, considered as the best curative option …