Viral capsids are often regarded as inert structural units, but in actuality they display
fascinating dynamics during different stages of their life cycle. With the advent of single …

Conspectus Viruses are unique among living organisms insofar as they can be reconstituted
“from scratch”, that is, synthesized from purified components. In the simplest cases, their …

RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery
and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely …

Highlights•Multiple, common dispersed packaging signals (PSs) promote RNA virus
assembly.•PS-mediated assembly solves a viral equivalent of Levinthal's Paradox.•RNA PSs …

Viruses, entities composed of nucleic acids, proteins, and in some cases lipids lack the
ability to replicate outside their target cells. Their components self-assemble at the …

Long RNA molecules are at the core of gene regulation across all kingdoms of life, while
also serving as genomes in RNA viruses. Few studies have addressed the basic physical …

RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …

The past decade has seen a revolution in our understanding of how the cellular environment
is organized, where an incredible body of work has provided new insights into the role …

The lifecycle, and therefore the virulence, of single-stranded (ss)-RNA viruses is regulated
not only by their particular protein gene products, but also by the secondary and tertiary …

Rhinoviruses (RVs) are the main cause of recurrent infections with rather mild symptoms
characteristic of the common cold. Nevertheless, RVs give rise to enormous numbers of …