The role of plasma membrane sodium/hydrogen exchangers in gastrointestinal functions: proliferation and differentiation, fluid/electrolyte transport and barrier integrity
K Nikolovska, UE Seidler, C Stock - Frontiers in Physiology, 2022 - frontiersin.org
The five plasma membrane Na+/H+ exchanger (NHE) isoforms in the gastrointestinal tract
are characterized by distinct cellular localization, tissue distribution, inhibitor sensitivities …
are characterized by distinct cellular localization, tissue distribution, inhibitor sensitivities …
Na+/H+ Exchangers (NHEs) in Mammalian Sperm: Essential Contributors to Male Fertility
CC Gardner, PF James - International Journal of Molecular Sciences, 2023 - mdpi.com
Na+/H+ exchangers (NHEs) are known to be important regulators of pH in multiple
intracellular compartments of eukaryotic cells. Sperm function is especially dependent on …
intracellular compartments of eukaryotic cells. Sperm function is especially dependent on …
Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation
Severe COVID-19 is characterized by an increase in the number and changes in the
function of innate immune cells including neutrophils. However, it is not known how the …
function of innate immune cells including neutrophils. However, it is not known how the …
Human Colonoid–Myofibroblast Coculture for Study of Apical Na+/H+ Exchangers of the Lower Cryptal Neck Region
A Salari, K Zhou, K Nikolovska, U Seidler… - International Journal of …, 2023 - mdpi.com
Cation and anion transport in the colonocyte apical membrane is highly spatially organized
along the cryptal axis. Because of lack of experimental accessibility, information about the …
along the cryptal axis. Because of lack of experimental accessibility, information about the …
Reduced surface pH and upregulated AE2 anion exchange in SLC26A3-deleted polarized intestinal epithelial cells
Loss of function mutations in the SLC26A3 gene cause chloride-losing diarrhea in mice and
humans. Although systemic adaptive changes have been documented in these patients and …
humans. Although systemic adaptive changes have been documented in these patients and …
Compromised NHE8 Expression Is Responsible for Vitamin D-Deficiency Induced Intestinal Barrier Dysfunction
Y Guo, Y Li, Z Tang, C Geng, X Xie, S Song, C Wang… - Nutrients, 2023 - mdpi.com
Objectives: Vitamin D (VitD) and Vitamin D receptor (VDR) are suggested to play protective
roles in the intestinal barrier in ulcerative colitis (UC). However, the underlying mechanisms …
roles in the intestinal barrier in ulcerative colitis (UC). However, the underlying mechanisms …