Alzheimer's disease (AD) is the most common type of dementia characterized by the
deposition of amyloid beta (Aβ) plaques and tau-neurofibrillary tangles in the brain. Visceral …

Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

Hypothalamic detection of elevated circulating glucose triggers suppression of endogenous
glucose production (EGP) to maintain glucose homeostasis. Antipsychotics alleviate …

Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through
mechanisms that include glucose toxicity, vascular damage and blood–brain barrier (BBB) …

The hypothalamus plays a major role in the regulation of food intake and energy
expenditure. In the last decade, it was demonstrated that consumption of high-fat diets …

O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a dynamic post-translational
modification that regulates thousands of proteins and almost all cellular processes. Aberrant …

In experimental models, hypothalamic dysfunction is a key component of the
pathophysiology of diet-induced obesity. Early after the introduction of a high-fat diet …

Simple Summary Reduced oxygen availability generates a number of adaptive features
across all the animal kingdom, and the goal of this study was targeting the mild-hypoxia …

Background. Dyslipidemia has become a critical global issue for public health, with
elevating prevalence and morbidity closely related to many cardiovascular diseases (CVD) …

Repeated bouts of high‐intensity interval training (HIIT) induce an improvement in
metabolism via plasticity of melanocortin circuits and attenuated hypothalamic inflammation …