Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …

Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even
organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon …

Background and Purpose—Adenosine in many types of RNAs can be converted to m6A (N6-
methyladenosine) which is a highly dynamic epitranscriptomic modification that regulates …

Intervertebral disc degeneration (IDD) is the main cause of lower back pain (LBP), and
puzzles massive individuals worldwide. Mesenchymal stem cells (MSCs) transplantation …

Objective: Present study focused on the influence of lncRNA MALAT1 on coronary
atherosclerotic heart disease (CAD) by regulating miR-15b-5p/MAPK1 and mTOR signaling …

Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently
attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates …

Background and Purpose—FTY720 is a known sphingosine 1–phosphate receptor agonist.
In the present study, we investigated the neuroprotective effect of postischemic …

In recent years the etiopathology of a number of debilitating diseases such as type 2
diabetes, arthritis, atherosclerosis, psoriasis, asthma, cystic fibrosis, sepsis, and ulcerative …

Ischemic postconditioning initially referred to a stuttering reperfusion performed immediately
after reperfusion, for preventing ischemia/reperfusion injury in both myocardial and cerebral …