Microbial networks are an increasingly popular tool to investigate microbial community
structure, as they integrate multiple types of information and may represent systems-level …

Closed-loop turbulence control is a critical enabler of aerodynamic drag reduction, lift
increase, mixing enhancement, and noise reduction. Current and future applications have …

Identifying master regulators of biological processes and mapping their downstream gene
networks are key challenges in systems biology. We developed a computational method …

The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Exhausted CD8+ T cells function poorly and are negatively regulated by inhibitory receptors.
Transcriptional profiling has identified gene expression changes associated with …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …

The mutually beneficial interactions between plants and their animal pollinators and seed
dispersers have been paramount in the generation of Earth's biodiversity. These mutualistic …