The hepatitis C virus (HCV) leads to chronic liver disease and affects more than 2% of the
world's population. Complications of the disease include fibrosis, cirrhosis and …

Background: Antagonizing the production of infectious viruses inside cells requires drugs
that can cross the cell membrane without harming the host cells. Objective: It is therefore …

A catalyst-free electrochemical [3+ 2] cycloaddition of azobenzenes with hexahydro-1, 3, 5-
triazines in the absence of any external oxidant is developed for constructing the 1, 2, 4 …

The cyclization of 2, 5-cyclohexadienones tethered to activated methylene groups was
studied. The substitution around the cyclohexadienone ring serves to regioselectively direct …

A visible‐light‐mediated cycloaddition of azobenzenes and nonstabilized azomethine ylides
has been developed to access 1, 2, 4‐triazolidines. With readily available organic dye rose …

The effects of ligand and substrate choice on the Pd-catalyzed cyclization of alkyne-tethered
cyclohexadienones were examined. In the presence of a chiral ligand, the enantioselectivity …

Infection with the hepatitis C virus represents a global public health threat given that an
estimated 170 million individuals are chronically infected and thus at risk for cirrhosis and …

Covering: January 1993 to August 2008This Highlight describes synthetic methods that
have enabled new strategic approaches to the synthesis of natural product targets as well as …

A mild amination of aryl C–H has been developed using laccase as a green and sustainable
catalyst, aerial O2 as the oxidant, with water being the only by-product. Various aromatic …

There are no approved therapeutics for the most deadly nonsegmented negative-strand
(NNS) RNA viruses, including Ebola (EBOV). To identify chemical scaffolds for the …