The major function of the respiratory epithelium was once thought to be that of a physical
barrier. However, it constitutes the interface between the internal milieu and the external …

Asthma is a chronic disease of the airways that has long been viewed predominately as an
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …

This best-selling resource has a worldwide reputation as the leader in its field. Focusing on
human immunology and biology, while also reporting on scientific experimentation and …

Recent advances in the knowledge of asthma pathobiology suggest that biological therapies
that target cytokines can be potentially useful for the treatment of this complex and …

Asthma is a chronic inflammatory airway disorder characterized by airway
hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients …

The type 3 fimbriae of Klebsiella pneumoniae are comprised of the major fimbrial subunit
(MrkA) and the adhesin (MrkD) that has previously been shown to mediate binding to …

Although Th-2–mediated inflammation is a key therapeutic target in asthma, its relationship
to altered structure and functions of the airways is largely unknown. In addition to …

Rationale: Damage to airway epithelium is followed by deposition of extracellular matrix
(ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from …

Rationale Asthmatic airway remodelling is characterized by myofibroblast hyperplasia and
subbasement membrane collagen deposition. We hypothesized that cytokines and growth …

Although corticosteroids have been used for a long time as a very effective therapy of airway
inflammatory diseases such as asthma, only recently the molecular basis of their mechanism …