Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin
is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1). A wide range of pro-oxidant …

Aceruloplasminemia (ACP) is a rare, adult-onset, autosomal recessive disorder,
characterized by systemic iron overload due to mutations in the Ceruloplasmin gene (CP) …

Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-
derived peptide hormone. Hepcidin inhibits iron entry into plasma by binding to and …

Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of
progressive neurodegenerative diseases characterized by iron deposition in the globus …

Abnormally high brain iron, resulting from the disrupted expression or function of proteins
involved in iron metabolism in the brain, is an initial cause of neuronal death in …

All cells in organisms ranging from yeast to humans utilize iron as a cofactor or structural
element of proteins that function in diverse and critical cellular functions. However …

ABSTRACT Introduction: Iron (Fe) and manganese (Mn) are essential nutrients for humans.
They act as cofactors for a variety of enzymes. In the central nervous system (CNS), these …

Aceruloplasminemia is an ultra-rare hereditary disorder caused by defective production of
ceruloplasmin. Its phenotype is characterized by iron-restricted erythropoiesis and tissue …

Anemia is defined by a deficiency of hemoglobin, an iron-rich protein that binds oxygen in
the blood. It can be due to multiple causes, either acquired or genetic. Alterations of genes …