[HTML][HTML] FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …
immune homeostasis and inhibit immune responses in various diseases, including cancer …
Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions
A Salminen - Journal of Molecular Medicine, 2021 - Springer
The functional competence of the immune system gradually declines with aging, a process
called immunosenescence. The age-related remodelling of the immune system affects both …
called immunosenescence. The age-related remodelling of the immune system affects both …
Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling
Rationale One hallmark of tumor-derived exosomes (TEX) is the promotion of cancer
progression by stimulating angiogenesis. This study was performed to evaluate the role of …
progression by stimulating angiogenesis. This study was performed to evaluate the role of …
Targeting immunogenic cell stress and death for cancer therapy
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …
stressors, occupies a central position in the development of novel anticancer treatments …
The immune regulatory role of adenosine in the tumor microenvironment
J Xing, J Zhang, J Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Adenosine, an immunosuppressive metabolite, is produced by adenosine triphosphate
(ATP) released from dying or stressed cells and is found at high levels in the tumor …
(ATP) released from dying or stressed cells and is found at high levels in the tumor …
Inhibitors of the CD73-adenosinergic checkpoint as promising combinatory agents for conventional and advanced cancer immunotherapy
Z Kurago, G Guo, H Shi, RJ Bollag, MW Groves… - Frontiers in …, 2023 - frontiersin.org
The cell surface enzyme CD73 is increasingly appreciated as a pivotal non-redundant
immune checkpoint (IC) in addition to PD-1/PD-L1 and CTLA-4. CD73 produces …
immune checkpoint (IC) in addition to PD-1/PD-L1 and CTLA-4. CD73 produces …
[HTML][HTML] N6-methyladenosine (m6A)-mediated messenger RNA signatures and the tumor immune microenvironment can predict the prognosis of hepatocellular …
S Shen, J Yan, Y Zhang, Z Dong, J Xing… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background N6-methyladenosine (m6A)-mediated ribonucleic acid (RNA) methylation is
considered to be the most significant and abundant epigenetic modification in eukaryotic …
considered to be the most significant and abundant epigenetic modification in eukaryotic …
Neuropathic pain: Mechanisms and therapeutic strategies
The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our
ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The …
ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The …
Purine metabolites in tumor-derived exosomes may facilitate immune escape of head and neck squamous cell carcinoma
Body fluids of patients with head and neck squamous cell carcinoma (HNSCC) are enriched
in exosomes that reflect properties of the tumor. The aim of this study was to determine …
in exosomes that reflect properties of the tumor. The aim of this study was to determine …
Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression
Background We investigated the role of A2B-adenosine receptor in regulating
immunosuppressive metabolic stress in the tumor microenvironment. Novel A2B-adenosine …
immunosuppressive metabolic stress in the tumor microenvironment. Novel A2B-adenosine …