Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the
pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to …

Galectin-3 is a versatile protein orchestrating several physiological and pathophysiological
processes in the human body. In the last decade, considerable interest in galectin-3 has …

Glioblastoma (GBM), the most common and lethal primary brain tumor, with a median
survival rate of only 15 months, remains incurable despite intensive multimodal treatment of …

The efficacy of cancer immunotherapy is limited, in part, by the multitude of
immunosuppressive mechanisms present within the tumor microenvironment (TME) …

The role of the host extracellular matrix (ECM) in infection tends to be neglected. However,
the complex interactions between invading pathogens, host tissues and immune cells occur …

The obese phenotype is characterized by a state of chronic low‐grade systemic
inflammation that contributes to the development of comorbidities, including nonalcoholic …

Osteal macrophages (osteomacs) contribute to bone homeostasis and regeneration. To
further distinguish their functions from osteoclasts, which share many markers and growth …

A combination therapy approach is required to improve tumor immune infiltration and patient
response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin …

Background PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical
mechanisms of tumor-induced immune suppression that contribute to immunotherapy …

Objective—Vascular adventitia encompasses progenitors and is getting recognized as the
major site of inflammation in early stage of atherosclerosis. However, the cellular atlas of the …