Role of stress in the pathogenesis of cancer

IG Lempesis, VE Georgakopoulou… - International …, 2023 - spandidos-publications.com
Stress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the
stressors, which are counteracted by various physiological and behavioural adaptive …

The emerging role of histone deacetylase inhibitors in cervical cancer therapy

I Psilopatis, N Garmpis, A Garmpi, K Vrettou, P Sarantis… - Cancers, 2023 - mdpi.com
Simple Summary Histone deacetylase inhibitors (HDACIs) are a relatively new drug class
with important effects on the epigenetic regulation in cancer, inducing cancer cell death …

Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth

N Duan, X Hu, H Qiu, R Zhou, Y Li, W Lu, Y Zhu… - Cell Death & …, 2023 - nature.com
Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as
the disease only becomes symptomatic at an advanced stage. Growing evidence suggests …

Diet‐derived ergothioneine induces necroptosis in colorectal cancer cells by activating the SIRT3/MLKL pathway

N D'Onofrio, E Martino, A Balestrieri, L Mele… - FEBS …, 2022 - Wiley Online Library
Ergothioneine (Egt) is a dietary amino acid which acts as an antioxidant to protect against
ageing‐related diseases. We investigated the anti‐cancer properties of Egt in colorectal …

Long non-coding RNA H19 enhances the pro-apoptotic activity of ITF2357 (a histone deacetylase inhibitor) in colorectal cancer cells

C Zichittella, M Loria, A Celesia, D Di Liberto… - Frontiers in …, 2023 - frontiersin.org
Introduction: Long non-coding RNA H19 (lncH19) is highly expressed in colorectal cancer
(CRC) and plays critical roles in tumor development, proliferation, metastasis, and drug …

Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

N Garmpis, C Damaskos, D Dimitroulis… - Journal of Personalized …, 2022 - mdpi.com
Background/Aim: There is a strong association between malignancy and histone
deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) are now being tested as …

[HTML][HTML] Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission

XL Liang, L Ouyang, NN Yu, ZH Sun, ZK Gui… - Journal of …, 2023 - Elsevier
Divisions at the periphery and midzone of mitochondria are two fission signatures that
determine the fate of mitochondria and cells. Pharmacological induction of excessively …

Preventive Methods for Colorectal Cancer Through Dietary Interventions: A Focus on Gut Microbiota Modulation

Y Zhong, Z Liu, Y Wang, S Cai, Z Qiao… - Food Reviews …, 2024 - Taylor & Francis
The imbalance of gut microbiota can significantly exacerbate or even directly contribute to
the development of colorectal cancer (CRC). Modulating the gut microbiota through dietary …

[HTML][HTML] Nano-energy interference: A novel strategy for blunting tumor adaptation and metastasis

F Teng, D Fu, CC Shi, A Xiong, MX Yang, C Su, M Lei… - Materials Today Bio, 2024 - Elsevier
Blunting the tumor's stress-sensing ability is an effective strategy for controlling tumor
adaptive survival and metastasis. Here, we have designed a cyclically amplified nano …

Epigenetic regulation in colorectal cancer: The susceptibility of microRNAs 145, 143 and 133b to DNA demethylation and histone deacetylase inhibitors

A Omar, D Govan, C Penny - Plos one, 2023 - journals.plos.org
Globally, colorectal cancer (CRC) is a major health concern. Despite improvements in CRC
treatment, mortality rates remain high. Genetic instability and epigenetic dysregulation of …